Fig. 17. DNA methylation regulates PTEN expression. (A) The protein levels of DNMT1, DNMT3a, and DNMT3b were analyzed by western blot in AIA and normal FLSs. (B) DNMT1 protein was recruited to the coding region of the PTEN gene in AIA FLSs according to a ChIP assay. PTEN mRNA levels were analyzed by q-PCR. All values are expressed as the mean ± SD. ^## P<0.01 vs. normal group.